Further Studies on the Mode of Action of Clostridium Welchii Type-D Epsilon Toxin
نویسندگان
چکیده
منابع مشابه
Physiologic Action of Clostridium Welchii (type
Recent work reported from this laboratory (1 to 7) has shown that clostridia grow and produce toxins readily in anoxic muscle in zivo, and that they are readily introduced into dog muscles during the course of traumatizing procedures. Moreover, our previous experiments have suggested that these and perhaps other bacteria may be responsible for a toxic factor contributing to shock in traumatizin...
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Isolates of Clostridium perfringens type D produce the potent epsilon-toxin (a CDC/U.S. Department of Agriculture overlap class B select agent) and are responsible for several economically significant enterotoxemias of domestic livestock. It is well established that the epsilon-toxin structural gene, etx, occurs on large plasmids. We show here that at least two of these plasmids are conjugative...
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Fusion protein technology represents the strategy to achieve rapid, efficient, and cost-effective proteinexpression. Epsilon and Beta toxins are the most potent Clostridial toxins and cause disease in animals.This study describes in silico fusion of Clostridium perfringens types D and B epsilon and beta toxin genesthat was used for cloning in E.coli. The etx and cpb genes were...
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Designing and producing a proper fusion construction is the most important problem of producing large quantities of a properly folded functional protein. This construction should have all necessary components of a real gene. A good designed fusion gene construction could be cloned into a good and suitable host. Clostridium perfringens is an important pathogen of humans and livestock and produce...
متن کاملMapping of the continuous epitopes displayed on the Clostridium perfringens type D epsilon-toxin
The epsilon toxin, produced by Clostridium perfringens, is responsible for enterotoxemia in ruminants and is a potential bioterrorism agent. In the present study, 15 regions of the toxin were recognized by antibodies present in the serum, with different immunodominance scales, and may be antigen determinants that can be used to formulate subunit vaccines.
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ژورنال
عنوان ژورنال: Journal of Medical Microbiology
سال: 1978
ISSN: 0022-2615,1473-5644
DOI: 10.1099/00222615-11-3-293